← Back to CoursesMolecular Neuroscience: Beginner

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Brain Development, Plasticity, and Learning

Manual: General · Subject: Molecular Neuroscience

Explain how the brain builds itself and changes through experience at the molecular level.

The changing brain

Development

During development, the nervous system forms cells, moves them to the right places, and connects them into circuits. Molecules guide growth, branching, and connection choice, so brain development is not random.

Plasticity

Plasticity is the brain's ability to change with experience. At the molecular level, this can involve changes in receptor number, synapse strength, gene expression, and protein synthesis.

Learning and memory

When you learn, certain synapses become stronger or weaker. This often depends on activity patterns and on signaling pathways that modify proteins or turn genes on and off.

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Beginner takeaway

Learning is not only a mental event; it is also a physical change in cells and synapses.

One simple view of plasticity

  1. 1

    Step 1: Experience activates neural circuits

  2. 2

    Step 2: Signals reach the nucleus and synapse

  3. 3

    Step 3: Proteins are modified or made

  4. 4

    Step 4: Synapses change strength

  5. 5

    Step 5: Future signaling is altered

What is neural plasticity?

Name one molecular change that can support learning.