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Gene Expression and Epigenetics in the Brain

Manual: General · Subject: Molecular Neuroscience

Learn how neurons turn genes on and off and how experience can influence gene activity.

Genes are not always active

Gene expression

Gene expression is the process by which a cell uses information from a gene to make RNA or protein. Different cells express different sets of genes, which is why neurons, muscle cells, and skin cells behave differently even though they contain the same DNA.

Regulation in neurons

Neurons constantly adjust gene expression in response to activity, development, and environment. This helps the brain adapt during learning, development, and recovery from injury.

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Epigenetics

Epigenetics refers to chemical and structural changes that affect gene activity without changing the DNA sequence itself.

Common epigenetic mechanisms

Examples include DNA methylation and histone modification. These mechanisms can make genes easier or harder to use, helping cells remember past conditions in a biological way.

What does epigenetics change?

What is gene expression?

Gene regulation terms

Gene expression
Using a gene to make a product
Epigenetics
Regulation without DNA sequence change
DNA methylation
A chemical modification often linked to reduced gene activity
Histone modification
A change affecting how tightly DNA is packaged