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Neurons: Structure and Electrical Signals

Manual: General · Subject: Molecular Neuroscience

Explain how neurons are built and how they generate and propagate electrical signals.

Neuron anatomy

Basic parts of a neuron

A neuron typically has dendrites, a cell body, and an axon. Dendrites receive input, the cell body integrates signals, and the axon carries information to other cells. The axon may end in terminals that connect to a synapse.

Electrical excitability

Neurons can produce electrical signals because their membranes maintain differences in ion concentration. Ions are charged atoms or molecules, such as Na+Na^+, K+K^+, Ca2+Ca^{2+}, and Cl−Cl^-. These charge differences create a membrane potential, which is the electrical voltage across the cell membrane.

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Key term

Membrane potential is the voltage difference across a cell membrane caused by unequal ion distribution.

Action potentials

When a neuron receives enough input, it can fire an action potential, a brief electrical impulse that travels along the axon. This signal depends on the coordinated opening and closing of ion channels, which are proteins that let specific ions cross the membrane.

How an action potential begins

  1. 1

    Step 1: Input depolarizes the neuron

  2. 2

    Step 2: Voltage-gated ion channels open

  3. 3

    Step 3: Ions move across the membrane

  4. 4

    Step 4: A rapid electrical spike travels down the axon

What is the main job of an axon?

What is an action potential?